PUBLICATIONS

  1. Young KZ, Lee SJ, Zhang X, Cartee NMP, Torres M, Keep SG, Gabbireddy SR, Fontana JL, Qi L, Wang MM. NOTCH3 is non-enzymatically fragmented in inherited cerebral small-vessel disease. Journal of Biological Chemistry. 2020 Jan 4. pii: jbc.RA119.007724. doi: 10.1074/jbc.RA119.007724. (Pubmed)
  2. Andjelkovic AV, Xiang J, Stamatovic SM, Hua Y, Xi G, Wang MM, Keep RF. Endothelial Targets in Stroke: Translating Animal Models to Human. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019 Nov;39(11):2240-2247. doi: 10.1161/ATVBAHA.119.312816. (Pubmed)
  3. Dean JG, Liu T, Huff S, Sheler B, Barker SA, Strassman RJ, Wang MM, Borjigin J. Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain. Scientific Reports. 2019 Jun 27;9(1):9333. doi: 10.1038/s41598-019-45812-w. (Pubmed)
  4. Tian F, Liu T, Xu G, Ghazi T, Sajjad A, Farrehi P, Wang MM, Borjigin J. Surge of corticocardiac coupling in SHRSP rats exposed to forebrain cerebral ischemia. Journal of Neurophysiology. 2019 Mar 1;121(3):842-852. doi: 10.1152/jn.00533.2018. (Pubmed)
  5. Xiang J, Andjelkovic AV, Zhou N, Hua Y, Xi G, Wang MM, Keep RF. Is there a central role for the cerebral endothelium and the vasculature in the brain response to conditioning stimuli? Conditioning Medicine. 2018 Aug;1(5):220-232. Epub 2018 Aug 31. (Pubmed)
  6. Xu M, Wang MM, Gao Y, Keep RF, Shi Y.
  7. Xu M, Wang MM, Gao Y, Keep RF, Shi Y. The effect of age-related risk factors and comorbidities on white matter injury and repair after ischemic stroke. Neurobiology of Disease. 2019 Jun;126:13-22. doi: 10.1016/j.nbd.2018.07.008. (Pubmed)
  8. Wang MM, Zhang X, Lee SJ, Maripudi S, Keep RF, Johnson AM, Stamatovic SM, Andjelkovic AV. Expression of periaxin (PRX) specifically in the human cerebrovascular system: PDZ domain-mediated strengthening of endothelial barrier function. Scientific Reports. 2018 Jul 3;8(1):10042. (Pubmed)
  9. Gatti JR, Zhang X, Korcari E, Lee SJ, Greenstone N, Dean JG, Maripudi S, Wang MM. Redistribution of Mature Smooth Muscle Markers in Brain Arteries in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. Translational Stroke Research. 2018 Jun 22. (Pubmed)
  10. Tian F, Liu T, Xu G, Li D, Ghazi T, Shick T, Sajjad A, Wang MM, Farrehi P, Borjigin J. Adrenergic Blockade Bi-directionally and Asymmetrically Alters Functional Brain-Heart Communication and Prolongs Electrical Activities of the Brain and Heart during Asphyxic Cardiac Arrest. Frontiers in Physiology. 2018 Feb 13;9:99. (Pubmed)
  11. Wang MM. CADASIL. Handbook of Clinical Neurology. 2018;148:733-743. (Pubmed)
  12. Lee SJ, Kwon S, Gatti JR, Korcari E, Gresser TE, Felix PC, Keep SG, Pasquale KC, Bai T, Blanchett-Anderson SA, Wu NW, Obeng-Nyarko C, Senagbe KM, Young KC, Maripudi S, Yalavarthi BC, Korcari D, Liu AY, Schaffler BC, Keep RF, Wang MM. Large-scale identification of human cerebrovascular proteins: Inter-tissue and intracerebral vascular protein diversity. PLoS One. 2017 Nov 30;12(11):e0188540. (Pubmed)
  13. Xiang J, Andjelkovic AV, Wang MM, Keep RF. Blood-brain barrier models derived from individual patients: a new frontier: An Editorial Highlight on 'An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells'. Journal of Neurochemistry. 2017 Mar;140(6):843-844. (Pubmed)
  14. Tsai EA, Gilbert MA, Grochowski CM, Underkoffler LA, Meng H, Zhang X, Wang MM, Shitaye H, Hankenson KD, Piccoli D, Lin H, Kamath BM, Devoto M, Spinner NB, Loomes KM. THBS2 Is a Candidate Modifier of Liver Disease Severity in Alagille Syndrome. Cellular and Molecular Gastroenterology and Hepatology. 2016 May 26;2(5):663-675.e2. (Pubmed)
  15. Frieler RA, Nadimpalli S, Boland LK, Xie A, Kooistra LJ, Song J, Chung Y, Won Cho K, Lumeng CN, Wang MM, Mortensen RM. Depletion of macrophages in CD11b diphtheria toxin receptor mice induces brain inflammation and enhances inflammatory signaling during traumatic brain injury. Brain Res. 2015 Jul 21. pii: S0006-8993(15)00537-5. doi: 10.1016/j.brainres.2015.07.011. (Pubmed)
  16. Li D, Mabrouk OS, Liu T, Tian F, Xu G, Rengifo S, Choi SJ, Mathur A, Crooks CP, Kennedy RT, Wang MM, Ghanbari H, Borjigin J. Asphyxia-activated corticocardiac signaling accelerates onset of cardiac arrest. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2073-82. doi: 10.1073/pnas.1423936112. Epub 2015 Apr 6. PubMed PMID: 25848007; PubMed Central PMCID: PMC4413312. (Pubmed)
  17. Zhang X, Lee SJ, Young MF, Wang MM. The small leucine-rich proteoglycan BGN accumulates in CADASIL and binds to NOTCH3. Transl Stroke Res. 2015 Apr;6(2):148-55. doi: 10.1007/s12975-014-0379-1. Epub 2015 Jan 13. PubMed PMID: 25578324; PubMed Central PMCID: PMC4359085. (Pubmed)
  18. Zhang X, Lee SJ, Young KZ, Josephson DA, Geschwind MD, Wang MM. Latent NOTCH3 epitopes unmasked in CADASIL and regulated by protein redox state. Brain Res. 2014 Oct 2;1583:230-6. doi: 10.1016/j.brainres.2014.08.018. Epub 2014 Aug 21. PubMed PMID: 25150590; PubMed Central PMCID: PMC4206828. (Pubmed)
  19. Keep RF, Wang MM, Xiang J, Hua Y, Xi G. Full steam ahead with remote ischemic conditioning for stroke. Transl Stroke Res. 2014 Oct;5(5):535-7. doi: 10.1007/s12975-014-0363-9. Epub 2014 Jul 24. PubMed PMID: 25053258; PubMed Central PMCID: PMC4187220. (Pubmed)
  20. Lee SJ, Zhang X, Wang MM. Vascular accumulation of the small leucine-rich proteoglycan decorin in CADASIL. Neuroreport. 2014 Sep 10;25(13):1059-63. doi: 10.1097/WNR.0000000000000230. PubMed PMID: 25026535; PubMed Central PMCID: PMC4126884. (Pubmed)
  21. Meng H, Zhang X, Lee SJ, Wang MM. Von Willebrand factor inhibits mature smooth muscle gene expression through impairment of Notch signaling. PLoS One. 2013 Sep 23;8(9):e75808. doi: 10.1371/journal.pone.0075808. eCollection 2013. PubMed PMID: 24086636; PubMed Central PMCID: PMC3781053. (Pubmed)
  22. Borjigin J, Lee U, Liu T, Pal D, Huff S, Klarr D, Sloboda J, Hernandez J, Wang MM, Mashour GA. Surge of neurophysiological coherence and connectivity in the dying brain. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14432-7. doi: 10.1073/pnas.1308285110. Epub 2013 Aug 12. PubMed PMID: 23940340; PubMed Central PMCID: PMC3761619. (Pubmed)
  23. Zhang X, Meng H, Wang MM. Collagen represses canonical Notch signaling and binds to Notch ectodomain. Int J Biochem Cell Biol. 2013 Jul;45(7):1274-80. doi: 10.1016/j.biocel.2013.03.020. Epub 2013 Apr 8. PubMed PMID: 23579095; PubMed Central PMCID: PMC3683383. (Pubmed)
  24. Dong H, Ding H, Young K, Blaivas M, Christensen PJ, Wang MM. Advanced intimal hyperplasia without luminal narrowing of leptomeningeal arteries in CADASIL. Stroke. 2013 May;44(5):1456-8. doi: 10.1161/STROKEAHA.111.000721. Epub 2013 Mar 12. PubMed PMID: 23482599; PubMed Central PMCID: PMC3641653. (Pubmed)
  25. Wang MM, Xi G, Keep RF. Should the STAIR criteria be modified for preconditioning studies? Transl Stroke Res. 2013 Feb;4(1):3-14. doi: 10.1007/s12975-012-0219-0. PubMed PMID: 23458885; PubMed Central PMCID: PMC3580874. (Pubmed)
  26. Frieler RA, Ray JJ, Meng H, Ramnarayanan SP, Usher MG, Su EJ, Berger S, Pinsky DJ, Lawrence DA, Wang MM, Mortensen RM. Myeloid mineralocorticoid receptor during experimental ischemic stroke: effects of model and sex. J Am Heart Assoc. 2012 Oct;1(5):e002584. doi: 10.1161/JAHA.112.002584. Epub 2012 Oct 25. PubMed PMID: 23316294; PubMed Central PMCID: PMC3541615. (Pubmed)
  27. Wang MM, Lee SJ, Kim J, Majersik JJ, Blaivas M, Borjigin J. ABO blood antigens define human cerebral endothelial diversity. Neuroreport. 2013 Jan 23;24(2):79-83. doi: 10.1097/WNR.0b013e32835c93a2. PubMed PMID: 23262469. (Pubmed)
  28. Meng H, Zhang X, Yu G, Lee SJ, Chen YE, Prudovsky I, Wang MM. Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3. PLoS One. 2012;7(9):e44964. doi: 10.1371/journal.pone.0044964. Epub 2012 Sep 18. PubMed PMID: 23028706; PubMed Central PMCID: PMC3445613. (Pubmed)
  29. Zhang X, Meng H, Blaivas M, Rushing EJ, Moore BE, Schwartz J, Lopes MB, Worrall BB, Wang MM. Von Willebrand Factor permeates small vessels in CADASIL and inhibits smooth muscle gene expression. Transl Stroke Res. 2012 Mar;3(1):138-45. doi: 10.1007/s12975-011-0112-2. Epub 2011 Oct 20. PubMed PMID: 22639698; PubMed Central PMCID: PMC3358806. (Pubmed)
  30. Dong H, Blaivas M, Wang MM. Bidirectional encroachment of collagen into the tunica media in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Brain Res. 2012 May 25;1456:64-71. doi: 10.1016/j.brainres.2012.03.037. Epub 2012 Mar 23. PubMed PMID: 22503071; PubMed Central PMCID: PMC3370335. (Pubmed)
  31. Lee SJ, Meng H, Elmadhoun O, Blaivas M, Wang MM. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy affecting an African American man: identification of a novel 15-base pair NOTCH3 duplication. Arch Neurol. 2011 Dec;68(12):1584-6. doi: 10.1001/archneurol.2011.781. PubMed PMID: 22159056. (Pubmed)
  32. Ahmed S, Meng H, Liu T, Sutton BC, Opp MR, Borjigin J, Wang MM. Ischemic stroke selectively inhibits REM sleep of rats. Exp Neurol. 2011 Dec;232(2):168-75. doi: 10.1016/j.expneurol.2011.08.020. Epub 2011 Aug 30. PubMed PMID: 21906592; PubMed Central PMCID: PMC3253351. (Pubmed)
  33. Calinescu AA, Liu T, Wang MM, Borjigin J. Transsynaptic activity-dependent regulation of axon branching and neurotrophin expression in vivo. J Neurosci. 2011 Sep 7;31(36):12708-15. doi: 10.1523/JNEUROSCI.2172-11.2011. PubMed PMID: 21900550; PubMed Central PMCID: PMC3174489. (Pubmed)
  34. He Y, Hua Y, Keep RF, Liu W, Wang MM, Xi G. Hemoglobin expression in neurons and glia after intracerebral hemorrhage. Acta Neurochir Suppl. 2011;111:133-7. doi: 10.1007/978-3-7091-0693-8_22. PubMed PMID: 21725744. (Pubmed)
  35. Meng H, Chen G, Zhang X, Wang Z, Thomas DG, Giordano TJ, Beer DG, Wang MM. Stromal LRP1 in lung adenocarcinoma predicts clinical outcome. Clin Cancer Res. 2011 Apr 15;17(8):2426-33. doi: 10.1158/1078-0432.CCR-10-2385. Epub 2011 Feb 15. PubMed PMID: 21325077; PubMed Central PMCID: PMC3079007. (Pubmed)
  36. Frieler RA, Meng H, Duan SZ, Berger S, Schütz G, He Y, Xi G, Wang MM, Mortensen RM. Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemia. Stroke. 2011 Jan;42(1):179-85. doi: 10.1161/STROKEAHA.110.598441. Epub 2010 Nov 24. PubMed PMID: 21106954; PubMed Central PMCID: PMC3042719. (Pubmed)
  37. He Y, Hua Y, Lee JY, Liu W, Keep RF, Wang MM, Xi G. Brain alpha- and beta-globin expression after intracerebral hemorrhage. Transl Stroke Res. 2010 Mar;1(1):48-56. doi: 10.1007/s12975-009-0004-x. PubMed PMID: 20563289; PubMed Central PMCID: PMC2887669. (Pubmed)
  38. Keep RF, Wang MM, Xiang J, Hua Y, Xi G. Is there a place for cerebral preconditioning in the clinic? Transl Stroke Res. 2010 Jan 14;1(1):4-18. doi: 10.1007/s12975-009-0007-7. PubMed PMID: 20563278; PubMed Central PMCID: PMC2887308. (Pubmed)
  39. Meng H, Zhang X, Lee SJ, Strickland DK, Lawrence DA, Wang MM. Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling. J Biol Chem. 2010 Jul 23;285(30):23047-55. doi: 10.1074/jbc.M110.144634. Epub 2010 May 14. PubMed PMID: 20472562; PubMed Central PMCID: PMC2906298. (Pubmed)
  40. Jia L, Yu G, Zhang Y, Wang MM. Lysosome-dependent degradation of Notch3. Int J Biochem Cell Biol. 2009 Dec;41(12):2594-8. doi: 10.1016/j.biocel.2009.08.019. Epub 2009 Sep 6. PubMed PMID: 19735738; PubMed Central PMCID: PMC2811749. (Pubmed)
  41. Lee SJ, Liu T, Chattoraj A, Zhang SL, Wang L, Lee TM, Wang MM, Borjigin J. Posttranscriptional regulation of pineal melatonin synthesis in Octodon degus. J Pineal Res. 2009 Aug;47(1):75-81. doi: 10.1111/j.1600-079X.2009.00690.x. Epub 2009 Jun 17. PubMed PMID: 19538336; PubMed Central PMCID: PMC2837936. (Pubmed)
  42. Stamatovic SM, Keep RF, Wang MM, Jankovic I, Andjelkovic AV. Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells. J Biol Chem. 2009 Jul 10;284(28):19053-66. doi: 10.1074/jbc.M109.000521. Epub 2009 May 7. PubMed PMID: 19423710; PubMed Central PMCID: PMC2707189. (Pubmed)
  43. Meng H, Zhang X, Blaivas M, Wang MM. Localization of blood proteins thrombospondin1 and ADAMTS13 to cerebral corpora amylacea. Neuropathology. 2009 Dec;29(6):664-71. doi: 10.1111/j.1440-1789.2009.01024.x. Epub 2009 Apr 28. PubMed PMID: 19422532; PubMed Central PMCID: PMC2871975. (Pubmed)
  44. Meng H, Peng Y, Hasan R, Yu G, Wang MM. Nuclear contrast angiography: a simple method for morphological characterization of cerebral arteries. Brain Res. 2009 Mar 19;1261:75-81. doi: 10.1016/j.brainres.2009.01.020. Epub 2009 Jan 22. PubMed PMID: 19401159; PubMed Central PMCID: PMC2784114. (Pubmed)
  45. Lee SJ, Chae C, Wang MM. p150/glued modifies nuclear estrogen receptor function. Mol Endocrinol. 2009 May;23(5):620-9. doi: 10.1210/me.2007-0477. Epub 2009 Feb 19. PubMed PMID: 19228793; PubMed Central PMCID: PMC2675952. (Pubmed)
  46. Meng H, Zhang X, Hankenson KD, Wang MM. Thrombospondin 2 potentiates notch3/jagged1 signaling. J Biol Chem. 2009 Mar 20;284(12):7866-74. doi: 10.1074/jbc.M803650200. Epub 2009 Jan 15. PubMed PMID: 19147503; PubMed Central PMCID: PMC2658079. (Pubmed)
  47. Meng H, Liu T, Borjigin J, Wang MM. Ischemic stroke destabilizes circadian rhythms. J Circadian Rhythms. 2008 Oct 15;6:9. doi: 10.1186/1740-3391-6-9. PubMed PMID: 18922153; PubMed Central PMCID: PMC2584098. (Pubmed)
  48. Huang Z, Liu T, Chattoraj A, Ahmed S, Wang MM, Deng J, Sun X, Borjigin J. Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland. J Pineal Res. 2008 Nov;45(4):506-14. doi: 10.1111/j.1600-079X.2008.00627.x. Epub 2008 Aug 13. PubMed PMID: 18705647; PubMed Central PMCID: PMC2669754. (Pubmed)
  49. Zhang Y, Jia L, Lee SJ, Wang MM. Conserved signal peptide of Notch3 inhibits interaction with proteasome. Biochem Biophys Res Commun. 2007 Mar 30;355(1):245-51. Epub 2007 Feb 5. Erratum in: Biochem Biophys Res Commun. 2007 Aug 3;359(3):840. PubMed PMID: 17292860; PubMed Central PMCID: PMC1839862. (Pubmed)
  50. Wang MM. Genetics of ischemic stroke: future clinical applications. Semin Neurol. 2006 Nov;26(5):523-30. Review. PubMed PMID: 17048154. (Pubmed)
  51. Wang MM, Traystman RJ, Hurn PD, Liu T. Non-classical regulation of estrogen receptor-alpha by ICI182,780. J Steroid Biochem Mol Biol. 2004 Sep;92(1-2):51-62. PubMed PMID: 15544930. (Pubmed)